Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea.

In 1960 spectinomycin, a new broad spectrum antibiotic, was released for clinical investigation and it was shown that the administration of 2 g. of the sulphate salt was effective therapy in acute gonorrhoea yielding cure rates of approximately 87 to 95 per cent. in males. The cure rate in females was 92 per cent. with a 3 g. dose (Laird and Taylor, 1962; Wilcox, 1963; Tiedemann, Hackney, and Price, 1965; Sparling, Yobs, Billings, and Hackney, 1966). In order to provide a more concentrated suspension for parenteral administration, a new hydrochloride salt has now been developed; it is the purpose of this paper to report the results of the administration of Trobicin hydrochloride.+§ This salt appears to be